Magnetic Resonance and Light Microscopy Investigation of Raw Cells Treated With Dextran-Based Magnetic Fluid

In the present study, magnetic resonance (MR) and light microscopy (LM) were used to investigate in vitro effects of dextran-coated magnetic nanoparticles (MNPs) on mouse Raw cells. LM showed the increasing internalization and metabolization of MNPs. MR allowed determination of fundamental parameter...

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Bibliographic Details
Published in:IEEE transactions on magnetics 2006-10, Vol.42 (10), p.3599-3601
Main Authors: Lacava, Z.G.M., Lacava, L.M., Fonseca, M.J.P., Souza, T.M.M., Pereira, L.O., Silva, O., Pelegrini, F., Sabolovic, D., Sestier, C., Azevedo, R., Buske, N., Morais, P.C.
Format: Article
Language:English
Subjects:
Biological
Biological systems
Biological tissues
Cell-particle interaction
Cells (biology)
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
In vitro
In vitro testing
magnetic fluid
Magnetic fluids
Magnetic force microscopy
Magnetic liquids
Magnetic resonance
Magnetism
magnetite nanoparticle
Materials science
Mice
Microscopy
Nanoparticles
Other topics in materials science
Physics
Raw
Raw cells
Spectroscopy
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Summary:In the present study, magnetic resonance (MR) and light microscopy (LM) were used to investigate in vitro effects of dextran-coated magnetic nanoparticles (MNPs) on mouse Raw cells. LM showed the increasing internalization and metabolization of MNPs. MR allowed determination of fundamental parameters, such as the MNP internalization half-life (t 1/2 ). The data evidenced that MR can be used as a key spectroscopic technique to investigate MNP internalization and cell/tissue interaction processes in biological systems
ISSN:0018-9464
1941-0069
DOI:10.1109/TMAG.2006.879448