Neurotransmitter systems of some brain regions of rats subjected to chronic morphine intoxication

The content of neurotransmitters and their metabolites was investigated in brain cortex hemispheres, thalamus and brainstem of rats subjected to chronic morphine intoxication (7–21 days). Morphine administration for 7–14 days was accompanied by changes of the catecholamine system functioning, which...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2011-06, Vol.5 (2), p.175-179
Main Authors: Lelevich, S. V., Novokshonov, A. A.
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Brain
Chemistry
Chemistry and Materials Science
Dopamine
Medicinal Chemistry
Narcotics
Neurochemistry
Neurotransmitters
Rodents
Serotonin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The content of neurotransmitters and their metabolites was investigated in brain cortex hemispheres, thalamus and brainstem of rats subjected to chronic morphine intoxication (7–21 days). Morphine administration for 7–14 days was accompanied by changes of the catecholamine system functioning, which was the most pronounced in the thalamus and the brainstem. These changes included increased secretion of dopamine and noradrenaline, their decrease in the brain tissue, and an increased content of their metabolites. The changes in serotonin and GABA content were less pronounced and included a decrease of serotonin level and the increase of the GABA content in different periods of opiate administration.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750811020065