Tec family kinases: regulation of Fc[epsilon]RI-mediated mast-cell activation

Mast cells express the high-affinity receptor for IgE (Fc[straight epsilon]RI) and are key players in typeI hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis, however, they also regulate normal physiological pro...

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Bibliographic Details
Published in:The FEBS journal 2011-06, Vol.278 (12), p.1990
Main Authors: Ellmeier, Wilfried, Abramova, Anastasia, Schebesta, Alexandra
Format: Article
Language:English
Subjects:
Cellular biology
Immunology
Kinases
Lymphocytes
Proteins
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Summary:Mast cells express the high-affinity receptor for IgE (Fc[straight epsilon]RI) and are key players in typeI hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis, however, they also regulate normal physiological processes that link innate and adaptive immune responses. Thus, their activation has to be tightly controlled. One group of signaling molecules that are activated upon Fc[straight epsilon]RI stimulation is formed by Tec family kinases, and three members of this kinase family (Btk, Itk and Tec) are expressed in mast cells. Many studies have revealed important functions of Tec kinases in signaling pathways downstream of the antigen receptors in lymphocytes. This review summarizes the current knowledge about the function of Tec family kinases in Fc[straight epsilon]RI-mediated signaling pathways in mast cell. Mast cells are key players in typeI hypersensitivity reactions, however they also regulate normal physiological processes that link innate and adaptive immune responses. Members of the Tec family of protein tyrosine kinases are crucial regulators of mast cell activation. Here we review the current knowledge about the role of Tec family kinases in Fc[straight epsilon]RI-mediated signaling pathways in the mast cell. [PUBLICATION ABSTRACT]
ISSN:1742-464X
1742-4658