Anti-hyperglycemic and antioxidant activities of the ayurvedic drug Nisha kathakathadhi churnam in alloxan-induced hyperglycemic rats

The anti-hyperglycemic and antioxidant potential of Nisha Kathakathadhi Churnam (NKC), an ayurvedic formulation, was estimated in alloxan-induced, hyperglycemic rats. Various enzymatic antioxidants, such as, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxi...

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Published in:International journal of green pharmacy 2009-01, Vol.3 (1), p.66
Main Authors: Jithendra, CH, Muralidharan, P
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Ayurvedic medicine
Chemical properties
Diabetes
Diabetic retinopathy
Drug therapy
Health aspects
Hyperglycemia
Lipid peroxidation
Medicine, Ayurvedic
Metabolic disorders
Metabolites
Monitoring systems
Oxidative stress
Pancreas
Pathogenesis
Permeability
Physiological aspects
Rodents
Superoxide dismutase
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Summary:The anti-hyperglycemic and antioxidant potential of Nisha Kathakathadhi Churnam (NKC), an ayurvedic formulation, was estimated in alloxan-induced, hyperglycemic rats. Various enzymatic antioxidants, such as, superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and lipid peroxidation were estimated in the heart and pancreas of hyperglycemic rats. The effect of NKC on blood glucose levels was estimated on days 0, 10, 20 and 30 of a 30-day study. A marked decrease in the blood glucose levels ( P < 0.001) was observed in hyperglycemic rats and the decreased activities of the key antioxidant enzymes increased to near normal (P< 0.01) levels and the increased lipid peroxidation decreased in diabetic rats upon NKC treatment. These results suggest that NKC has promising antidiabetic and antioxidant activities in alloxan-induced diabetes.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.49378