Hepatoprotective activity of Trianthema decandra on carbon tetrachloride-induced hepatotoxicity in rats

The present study appraised the hepatoprotective activity of aqueous extract of Trianthema decandra roots against carbon tetrachloride-induced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and olive oil (50% v/v, 0.5 ml/kg) in ma...

Full description

Saved in:
Bibliographic Details
Published in:International journal of green pharmacy 2008-04, Vol.2 (2), p.122
Main Authors: Sengottuvelu, Singaravel, Srinivasan, Duraisamy, Duraisami, Rasilingam, Nandhakumar, Jothivel, Vasudevan, Mani, Sivakumar, Thangavel
Format: Article
Language:English
Subjects:
Care and treatment
Health aspects
Herbal medicine
Liver
Liver diseases
Medicinal plants
Pharmacology
Properties
Risk factors
Rodents
Weeds
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study appraised the hepatoprotective activity of aqueous extract of Trianthema decandra roots against carbon tetrachloride-induced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and olive oil (50% v/v, 0.5 ml/kg) in male Wistar rats (150-220 g) once daily for 7 days and the extent of damage was studied by assessing the biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin in serum. The aqueous extract of Trianthema decandra roots (50 mg, 100 mg and 200 mg/kg) were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its effects on biochemical parameters were compared with Silymarin (25 mg/kg) treated animals. Trianthema decandra (100 and 200 mg/kg) results in a significant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. There was a significant increase in the serum total protein and albumin when compared to rats treated with carbon tetrachloride alone. The results concludes that the aqueous extract of Trianthema decandra roots (100 and 200 mg/kg) has protected the liver from carbon tetrachloride-induced damage.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.41187