Tissue-engineered fascia from vaginal fibroblasts for patientsneeding reconstructive pelvic surgery

Introduction and hypothesis Mesh-augmented reconstructive surgery for pelvic organ prolapse (POP) does not meet clinical expectations. A tissue-engineered fascia equivalent needs to be developed. Methods Human vaginal fibroblasts (HVFs) from 10 patients were characterized in vitro. Eligible HVFs and...

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Bibliographic Details
Published in:International Urogynecology Journal 2010-09, Vol.21 (9), p.1085-1093
Main Authors: Hung, Man-Jung, Wen, Mei-Chin, Hung, Chia-Nung, Ho, Esther Shih-Chu, Chen, Gin-Den, Yang, Vivian Cheng
Format: Article
Language:English
Subjects:
Gynecology
Medicine
Medicine & Public Health
Original Article
Urology
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Summary:Introduction and hypothesis Mesh-augmented reconstructive surgery for pelvic organ prolapse (POP) does not meet clinical expectations. A tissue-engineered fascia equivalent needs to be developed. Methods Human vaginal fibroblasts (HVFs) from 10 patients were characterized in vitro. Eligible HVFs and a biodegradable scaffold were used to fabricate a fascia equivalent, which was then transplanted in vivo. Results The cultured HVFs were divided into high ( n  = 6) or low ( n  = 4) collagen I/III ratio groups. Cells of the high-ratio group exhibited significantly higher proliferation potential than those of the low-ratio group ( P  
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-010-1168-3