Efficient One-Pot Synthesis of 4-Aroyl-2-pyrones: Nucleophilic Addition of Active Methylene Groups to 1,2-Diaroylacetylenes

An efficient synthesis of 3,6-disubstituted-4-aroyl-2-pyrones in a single-step reaction through Michael addition of 1,2-diaroylacetylenes with active methylene compounds in the presence of NaH in dimethylsulfoxide at room temperature is reported. The structures have been confirmed by spectral data a...

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Bibliographic Details
Published in:Synthetic communications 2011-09, Vol.41 (18), p.2738-2746
Main Authors: Shankar, Ravi, Shukla, Harsha, Singh, Uma Sharan, Thakur, Vinay, Hajela, K.
Format: Article
Language:English
Subjects:
1,2-diaroylacetylenes
4-Aroyl-2-pyrones
Michael addition
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Summary:An efficient synthesis of 3,6-disubstituted-4-aroyl-2-pyrones in a single-step reaction through Michael addition of 1,2-diaroylacetylenes with active methylene compounds in the presence of NaH in dimethylsulfoxide at room temperature is reported. The structures have been confirmed by spectral data analyses.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2010.515350