Predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia

• Published in: Supportive care in cancer 2011-08, Vol.19 (8), p.1151-1158
• Main Authors: Ahn, Shin, Lee, Yoon-Seon, Chun, Yun-Hee, Kwon, In-Ho, Kim, Won, Lim, Kyung Soo, Kim, Tae Won, Lee, Kyoo-Hyung
• Format: Article
• Language: English
• Subjects: Analysis; Antineoplastic Agents - adverse effects; Blood diseases; C-Reactive Protein; Cancer; Cancer patients; Chemotherapy; Clinical outcomes; Complications and side effects; Confidence Intervals; Female; Fever - chemically induced; Humans; Internationality; Logistic Models; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Neoplasms - complications; Neoplasms - drug therapy; Neutropenia; Neutropenia - chemically induced; Nursing; Nursing Research; Odds Ratio; Oncology; Original Article; Pain Medicine; Prognosis; Rehabilitation Medicine; Retrospective Studies; Risk Assessment
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-010-0928-4

Objectives We intended to determine the predictive factors of poor prognosis in cancer patients with chemotherapy-induced febrile neutropenia (FN). Methods From January 1, 2007 to December 31, 2008, 396 episodes of FN in 346 cancer patients were retrospectively analyzed. Clinical and laboratory findings and Multinational Association of Supportive Care in Cancer (MASCC) risk-index score were analyzed and correlated with outcome. Results Of the 396 episodes, 73 (18.4%) had serious medical complications including 15 (3.8%) deaths. There was significant difference between unfavorable and favorable outcomes in age, gender, hypotension, tachypnea, duration of fever ≤24 h before admission (44.4% vs. 61.3%), interval of ≤7 days since last chemotherapy (34.2% vs. 16.1%), and duration of neutropenia ≥4 days (34.2% vs. 15.8%; P