Interactions of [alpha]-Lactalbumin and Cytochrome c with Langmuir Monolayers of Glycerophospholipids

Interaction of cytochrome c (Cyt c), α-lactalbumin III (α-La III) with Langmuir monolayers of pure and mixed glycerophospholipids was investigated using surface pressure-area (Π-A) isotherms. The general trend was that maximum interaction between protein and phospholipid is observed for mixed (1:1 m...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2011-02, Vol.32 (2), p.150
Main Authors: Glomm, Wilhelm R, Volden, Sondre, Ese, Marit-Helen Glomm, Halskau Jr, Øyvind
Format: Article
Language:English
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Summary:Interaction of cytochrome c (Cyt c), α-lactalbumin III (α-La III) with Langmuir monolayers of pure and mixed glycerophospholipids was investigated using surface pressure-area (Π-A) isotherms. The general trend was that maximum interaction between protein and phospholipid is observed for mixed (1:1 molar ratio) phospholipid monolayers. Interaction between the protein and the charged phospholipid films was found to be independent of global protein charge. Our data indicate that the proteins interact with the phospholipid films by inserting themselves into the monolayer rather than anchoring to the phospholipid head groups.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932690903543287