Metastatic psammomatous somatostatioma of the pancreas causing severe ketoacidotic diabetes cured by surgery

A case of somatostatin-producing pancreatic tumor associated with severe insulindependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdomina...

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Bibliographic Details
Published in:Endocrine pathology 1997-12, Vol.8 (4), p.327-333
Main Authors: Sessa, Fausto, Arcidiaco, Massimo, Valenti, Luigi, Solcia, Marco, Di Maggio, Enrico, Solcia, Enrico
Format: Article
Language:English
Subjects:
Cancer
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Summary:A case of somatostatin-producing pancreatic tumor associated with severe insulindependent diabetes mellitus and ketoacidotic coma is reported. The tumor, a 10-cm expansile mass arising from the pancreatic tail of a 70-yr-old woman, was first detected by ultrasonography, performed because of abdominal pain, and subsequently confirmed by computed tomography and fine-needle tumor aspiration. Pathologic investigation showed a predominatly solid-trabecular structure with scattered microacini and psammomatous bodies. A large proportion of tumor cells expressed somatostatin and/or calcitonin. Following resection of the primary tumor and three peripancreatic lymph nodes with metastases, the patient recovered rapidly from her diabetic syndrome and remained in substantially good health during a subsequent 8-yr follow-up period, without evidence of tumor recurrence.[PUBLICATION ABSTRACT]
ISSN:1046-3976
1559-0097
DOI:10.1007/BF02739935