Effect of alfuzosin on female primary bladder neck obstruction

Our objective was to assess the effect of the selective α 1 -blocker alfuzosin on urodynamic parameters and quality of life in female patients with primary bladder neck obstruction (PBNO). Twenty-five women identified as having PBNO were included in the study. After the initial assessment of urodyna...

Full description

Saved in:
Bibliographic Details
Published in:International Urogynecology Journal 2009-02, Vol.20 (2), p.217-222
Main Authors: Athanasopoulos, A., Gyftopoulos, K., Giannitsas, K., Perimenis, P.
Format: Article
Language:English
Subjects:
Gynecology
Medicine
Medicine & Public Health
Original Article
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our objective was to assess the effect of the selective α 1 -blocker alfuzosin on urodynamic parameters and quality of life in female patients with primary bladder neck obstruction (PBNO). Twenty-five women identified as having PBNO were included in the study. After the initial assessment of urodynamic parameters and bother score index, all patients were treated with alfuzosin 5 mg twice daily for 8 weeks. After this period of time, the patients were reassessed with the same methodology as pretreatment. Symptoms subjectively improved, and patients’ satisfaction significantly increased in 64% of the patients (16 out of 25). Most urodynamic parameters were also significantly improved after treatment with alfuzosin. Alfuzosin significantly improved urodynamic parameters and alleviated bother score in almost two thirds of patients with PBNO and can be an effective first-line treatment of this situation.
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-008-0749-x