Retrobulbar optic neuritis after pamidronate administration in a patient with a history of cutaneous porphyria

We describe the case of a patient who developed reversible retrobulbar optic neuritis after intravenous pamidronate therapy for established osteoporosis. This possible complication has never been previously reported and, since our patient had a history of porphyria, it suggests that bisphosphonates...

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Bibliographic Details
Published in:Clinical rheumatology 1997-01, Vol.16 (1), p.93-95
Main Authors: des Grottes, J M, Schrooyen, M, Dumon, J C, Body, J J
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - therapeutic use
Diphosphonates - administration & dosage
Diphosphonates - adverse effects
Evoked Potentials, Visual
Female
Humans
Infusions, Intravenous
Middle Aged
Optic nerve
Optic Neuritis - chemically induced
Optic Neuritis - diagnosis
Optic Neuritis - drug therapy
Osteoporosis, Postmenopausal - complications
Osteoporosis, Postmenopausal - drug therapy
Pamidronate
Porphyrias - complications
Prednisolone - therapeutic use
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Summary:We describe the case of a patient who developed reversible retrobulbar optic neuritis after intravenous pamidronate therapy for established osteoporosis. This possible complication has never been previously reported and, since our patient had a history of porphyria, it suggests that bisphosphonates should be administered cautiously in patients with this disease.
ISSN:0770-3198
1434-9949
DOI:10.1007/BF02238770