The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS)

Objective: To test whether cannabinoids reduce urge incontinence episodes without affecting voiding in patients with multiple sclerosis. This was part of the multicentre trial of the Cannabinoids in Multiple Sclerosis (CAMS) study. Subjects and methods: The CAMS study randomised 630 patients to rece...

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Bibliographic Details
Published in:International Urogynecology Journal 2006-11, Vol.17 (6), p.636-641
Main Authors: Freeman, R. M., Adekanmi, O., Waterfield, M. R., Waterfield, A. E., Wright, D., Zajicek, J.
Format: Article
Language:English
Subjects:
Drug therapy
Multiple sclerosis
Urinary incontinence
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Summary:Objective: To test whether cannabinoids reduce urge incontinence episodes without affecting voiding in patients with multiple sclerosis. This was part of the multicentre trial of the Cannabinoids in Multiple Sclerosis (CAMS) study. Subjects and methods: The CAMS study randomised 630 patients to receive oral administration of cannabis extract, Δ^sup 9^-tetrahydrocannabinol (THC) or matched placebo. For this substudy subjects completed incontinence diaries. Results: All three groups showed a significant reduction, p
ISSN:0937-3462
1433-3023
DOI:10.1007/s00192-006-0086-x