Deficiency of muscle [alpha]-actinin-3 is compatible with high muscle performance

Long-distance runners generally have a remarkably high proportion of slow type I fibers in their lower muscle groups. However, the transformation of type II fast fibers to slow type I fibers as a result of exercise has not been demonstrated clearly. We report the analysis of muscle type composition...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2003-02, Vol.20 (1), p.39
Main Authors: Zanoteli, Edmar, Lotuffo, Renato M, Oliveira, Acary S, B, Beggs, Alan H, Canovas, Marta, Zatz, Mayana, Vainzof, Mariz
Format: Article
Language:English
Subjects:
Muscular system
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Summary:Long-distance runners generally have a remarkably high proportion of slow type I fibers in their lower muscle groups. However, the transformation of type II fast fibers to slow type I fibers as a result of exercise has not been demonstrated clearly. We report the analysis of muscle type composition on m. vastus lateralis from six endurance athletes through the expression of fast, slow, and developmental myosin isoforms, and α-actinin-3 (ACTN3) protein. Only one among the marathon runners presented evident type I fiber predominance, and surprisingly, a second athlete showed a deficiency of ACTN3. The deficiency of ACTN3 in the muscle tissue of endurance athletes confirmed the redundancy of this protein for muscle function, even in muscles that are highly required.[PUBLICATION ABSTRACT]
ISSN:0895-8696
1559-1166
DOI:10.1385/JMN:20:1:39