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Metalloantitubercular compounds Part 3: Synthesis, crystal structure, spectroscopy, electrochemistry and antimycobacterial activity of the copper(II) ciproploxacin (cfH) complex and its phenanthroline adduct

The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)^sub 2^(Cl)^sub 2^] · ^sub 2^MeOH · 6H^sub 2^O (2) and [Cu(cfH)(phen)Cl]BF^sub 4^ · 4H^sub 2^O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal...

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Bibliographic Details
Published in:Transition metal chemistry (Weinheim) 2005-04, Vol.30 (3), p.334-340
Main Authors: Saha, Dilip Kumar, Patitungkho, Sommai, Padhye, Subhash, Deobagkar, Dileep N., Ozarkar, Aarti, Bhadbhade, Mohan M., Gonnade, Rajesh G.
Format: Article
Language:English
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Summary:The X-ray crystal structures of two ciprofloxacin compounds, viz. [Cu(cfH)^sub 2^(Cl)^sub 2^] · ^sub 2^MeOH · 6H^sub 2^O (2) and [Cu(cfH)(phen)Cl]BF^sub 4^ · 4H^sub 2^O (3) are reported. Complex (2) has a distorted octahedral geometry, whereas for the nitrogen adduct (3) a distorted square-pyramidal geometry is seen. Significant enhancement in the antimycobacterial activity of the copper conjugates correlates with their copper redox couples (Cu^sup 2+^ /Cu^sup +^) probably due to its relevance to intracellular accumulations and subsequent role in generating oxidative stress.[PUBLICATION ABSTRACT]
ISSN:0340-4285
1572-901X
DOI:10.1007/s11243-004-5861-2