Prevention of cisplatin-induced delayed emesis : still unsatisfactory

The incidence of and prognostic factors in cisplatin-induced delayed emesis were evaluated in 522 naive cancer patients. They each received an intravenous combination of ondansetron and one of four different doses of dexamethasone for the prevention of acute emesis and a combination of orally admini...

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Bibliographic Details
Published in:Supportive care in cancer 2000-05, Vol.8 (3), p.229-232
Main Author: Roila, F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Digestive system
Drug toxicity and drugs side effects treatment
Medical sciences
Pharmacology. Drug treatments
Toxicity: digestive system
Vomiting
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Summary:The incidence of and prognostic factors in cisplatin-induced delayed emesis were evaluated in 522 naive cancer patients. They each received an intravenous combination of ondansetron and one of four different doses of dexamethasone for the prevention of acute emesis and a combination of orally administered metoclopramide plus intramuscular dexamethasone for the prevention of delayed emesis. Despite the best prophylaxis for acute and delayed emesis, 37.4% / 57.1% of patients experienced delayed vomiting / nausea. The presence of acute vomiting / nausea was the main prognostic factor in delayed vomiting / nausea; therefore, a multifactorial analysis of the results achieved during the delayed phase adjusted for those obtained during the acute phase should be carried out in every study evaluating the efficacy of different antiemetic drugs for delayed emesis.[PUBLICATION ABSTRACT]
ISSN:0941-4355
1433-7339
DOI:10.1007/s005200050290