A case of ochronosis with gout and monckeberg arteries

Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age...

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Bibliographic Details
Published in:Rheumatology international 2009-10, Vol.29 (12), p.1507-1510
Main Authors: Karimzadeh, Hadi, Mohtasham, Negin, Karimifar, Mansoor, Salesi, Mansour, Bonakdar, Zahra Sayed
Format: Article
Language:English
Subjects:
Aged
Allopurinol - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Bacteria
Case Report
Gout - diagnosis
Gout - drug therapy
Gout - etiology
Gout Suppressants - therapeutic use
Hand - diagnostic imaging
Humans
Male
Medicine
Medicine & Public Health
Monckeberg Medial Calcific Sclerosis - diagnosis
Monckeberg Medial Calcific Sclerosis - drug therapy
Monckeberg Medial Calcific Sclerosis - etiology
Ochronosis - complications
Ochronosis - diagnosis
Prednisolone - therapeutic use
Radiography
Rheumatology
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Summary:Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age in adults. Accumulation also occurs in heart valves, and there may be a predisposition to atherosclerosis. We describe a 72-year-old man with ochronosis, gouty arthritis of both hands, and monckeberg arteries.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-009-0882-y