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A case of ochronosis with gout and monckeberg arteries
Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age...
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Published in: | Rheumatology international 2009-10, Vol.29 (12), p.1507-1510 |
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creator | Karimzadeh, Hadi Mohtasham, Negin Karimifar, Mansoor Salesi, Mansour Bonakdar, Zahra Sayed |
description | Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age in adults. Accumulation also occurs in heart valves, and there may be a predisposition to atherosclerosis. We describe a 72-year-old man with ochronosis, gouty arthritis of both hands, and monckeberg arteries. |
doi_str_mv | 10.1007/s00296-009-0882-y |
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subjects | Aged Allopurinol - therapeutic use Anti-Inflammatory Agents - therapeutic use Bacteria Case Report Gout - diagnosis Gout - drug therapy Gout - etiology Gout Suppressants - therapeutic use Hand - diagnostic imaging Humans Male Medicine Medicine & Public Health Monckeberg Medial Calcific Sclerosis - diagnosis Monckeberg Medial Calcific Sclerosis - drug therapy Monckeberg Medial Calcific Sclerosis - etiology Ochronosis - complications Ochronosis - diagnosis Prednisolone - therapeutic use Radiography Rheumatology |
title | A case of ochronosis with gout and monckeberg arteries |
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