Streaming dielectrophoresis for continuous-flow microfluidic devices

This article describes the engineering development of a continuous-flow, selective particle filter/concentrator that works by a competition between dielectrophoresis (DEP) and electrokinesis (EK) in a microfluidic circuit. It was shown that a broad range of devices can used ideal EK and DEP in a var...

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Bibliographic Details
Published in:IEEE engineering in medicine and biology magazine 2003-11, Vol.22 (6), p.75-84
Main Author: Cummings, E.B.
Format: Article
Language:English
Subjects:
Analytical models
Arrays
Biopolymers - isolation & purification
Cell Separation - methods
Circuits
Computer-Aided Design
Design methodology
Devices
Dielectrophoresis
Electric fields
Electric potential
Electrophoresis - instrumentation
Electrophoresis - methods
Equipment Design - methods
Fabrication
Flow Cytometry - instrumentation
Flow Cytometry - methods
Heat transfer
Microelectrodes
Microfluidics
Microfluidics - instrumentation
Microfluidics - methods
Microorganisms
Nanotechnology - instrumentation
Nanotechnology - methods
Particle filters
Robustness
Run time (computers)
Trapping
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Summary:This article describes the engineering development of a continuous-flow, selective particle filter/concentrator that works by a competition between dielectrophoresis (DEP) and electrokinesis (EK) in a microfluidic circuit. It was shown that a broad range of devices can used ideal EK and DEP in a variety of modes. Because these transport mechanisms are proportional to different powers of the electric field, the devices can be tuned at run time to select different classes of particles and even to switch flow regimes from streaming to trapping dielectrophoresis by varying the applied voltage. As observed experimentally and numerically, streaming dielectrophoresis is a novel flow regime for device development. It can be coherently reinforced within a patterned array to produce strong particle "depletion" and "enhancement" effects.
ISSN:0739-5175
1937-4186
DOI:10.1109/MEMB.2003.1266050