Two multichannel integrated circuits for neural recording and signal processing

We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2003-02, Vol.50 (2), p.255-258
Main Authors: Obeid, I., Morizio, J.C., Moxon, K.A., Nicolelis, M.A.L., Wolf, P.D.
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Amplifiers, Electronic
Animals
Array signal processing
Biological and medical sciences
Circuit testing
CMOS analog integrated circuits
Differential amplifiers
Electrodes
Electrodes, Implanted
Electrophysiology - instrumentation
Equipment Design
Feasibility Studies
Filtering
Filters
Haplorhini
Integrated circuit manufacture
Integrated circuit testing
Medical sciences
Miniaturization
Neurons - physiology
Pilot Projects
Quality Control
Rats
Semiconductors
Signal processing
Somatosensory Cortex - physiology
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Summary:We have developed, manufactured, and tested two analog CMOS integrated circuit "neurochips" for recording from arrays of densely packed neural electrodes. Device A is a 16-channel buffer consisting of parallel noninverting amplifiers with a gain of 2 V/V. Device B is a 16-channel two-stage analog signal processor with differential amplification and high-pass filtering. It features selectable gains of 250 and 500 V/V as well as reference channel selection. The resulting amplifiers on Device A had a mean gain of 1.99 V/V with an equivalent input noise of 10 /spl mu/V/sub rms/. Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 /spl mu/V/sub rms/. Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2002.807643