Effectiveness of doxazosin on erectile dysfunction in patients with lower urinary tract symptoms

• Published in: International urology and nephrology 2011-09, Vol.43 (3), p.619-624
• Main Authors: Faydaci, Gokhan, Kuyumcuoglu, Ugur, Eryildirim, Bilal, Aktas, Alper, Tarhan, Fatih, Tuncer, Murat
• Format: Article
• Language: English
• Subjects: Adrenergic alpha-1 Receptor Antagonists - therapeutic use; Doxazosin - therapeutic use; Erectile Dysfunction - complications; Erectile Dysfunction - drug therapy; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Prostatism - complications; Prostatitis - complications; Severity of Illness Index; Urology; Urology – Original Paper
• ISSN: 0301-1623; 1573-2584
• DOI: 10.1007/s11255-010-9847-z

Objective We evaluated the effectiveness of doxazosin on ED in patients with LUTS/BPH and ED by using symptom score scales. We also evaluated whether or not the presence of asymptomatic inflammatory prostatitis had an effect on the alteration in the symptom scores. Patients and Methods A total of 36 male patients were included in the study. For all the cases, “International Prostate Symptom Score” (IPSS), “National Health Institute Chronic Prostatitis Symptom Index” (NIH-CPSI) and “International Index of Erectile Function” (IIEF-5) were investigated, and the scores were calculated in the first visit. Doxazosin was given for 30 days, and at the second visit IPSS, NIH-CPSI and IIEF-5 scores, Qmax and PMR were once more analysed. Afterwards, the alterations of the scores between visits were statistically compared. Results Mean age of the 36 cases included in the study was 59.03 ± 1.35. The alterations in parameters between 1st and 2nd visit were compared in the cases who used doxazosin and a statistically significant decrease in IPSS, NIH-CPSI scores and statistically significant increase in Qmax were observed. Besides, there was a statistically significant increase in IIEF-5 score. In addition, when the cases were divided into two groups patients with asymptomatic inflammatory prostatitis and without asymptomatic inflammatory prostatitis, there was not any difference in all scores. Conclusion Doxazocin use in cases with LUTS/BPH and ED has an improving effect on ED as well as LUTS. Therefore, we believe that in the future, single agents or combined therapies might have a place in cases with LUTS/BPH and ED.