Microwave thermochemotherapy in the treatment of the bladder carcinoma-electromagnetic and dielectric studies-clinical protocol

Microwave thermotherapy is currently used in clinical routines for benign prostatic hyperplasia treatments. The temperature increase is obtained using an endocavitary microwave applicator placed in the prostatic urethra. This urethral applicator after a technical modification can be placed inside th...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2000-05, Vol.47 (5), p.633-641
Main Authors: Dietsch, A., Camart, J.-C., Sozanski, J.-P., Prevost, B., Mauroy, B., Chive, M.
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - administration & dosage
Applicators
Biological and medical sciences
Bladder
Combined Modality Therapy
Dielectrics
Disease Models, Animal
Dogs
Electromagnetic Fields
Electromagnetic heating
Electromagnetic propagation
Finite difference method
Finite Element Analysis
Frequency response
Hyperthermia, Induced - instrumentation
Mathematical models
Medical sciences
Medical treatment
Microwave technology
Microwaves
Microwaves - therapeutic use
Mitomycin - administration & dosage
Nephrology. Urinary tract diseases
Oncology
Permittivity
Permittivity measurement
Protocols
Radiometry
Temperature
Temperature measurement
Time domain analysis
Tumors of the urinary system
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - therapy
Urinary tract. Prostate gland
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Summary:Microwave thermotherapy is currently used in clinical routines for benign prostatic hyperplasia treatments. The temperature increase is obtained using an endocavitary microwave applicator placed in the prostatic urethra. This urethral applicator after a technical modification can be placed inside the bladder in order to potentiate the effects of the treatment by chemotherapy of vesical carcinoma. This paper deals with electromagnetic studies of this new endocavitary applicator. First of all, the experimental determination of the dielectric permittivities for the propagation domain characterization is achieved in order to be used in the electromagnetic model. Compared to experimental results, these simulations obtained by the finite-difference time-domain formalism allow us to determine the electromagnetic performance of this applicator. Finally, the in vivo study realized on anesthetized dogs to determine the therapeutic protocol associating chemotherapy and thermotherapy in the treatment of the bladder cancer is presented.
ISSN:0018-9294
1558-2531
DOI:10.1109/10.841335