Integrating microfabricated fluidic systems and NMR spectroscopy

The philosophy of miniature total analysis systems (/spl mu/-TAS) hinges on the multiple chemical processing steps and the means of analyzing their results on the same miniaturized system. We have constructed chip-based capillary electrophoresis (CE) devices equipped with an integrated planar radio-...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2000-01, Vol.47 (1), p.3-7
Main Authors: Trumbull, J.D., Glasgow, I.K., Beebe, D.J., Magin, R.L.
Format: Article
Language:English
Subjects:
Chemical analysis
Chemical processes
Coiling
Devices
Dichotomies
Electrokinetics
Electrophoresis
Electrophoresis, Capillary
Equipment Design
Fasteners
Fluidic microsystems
Fluidics
Magnetic analysis
Magnetic Resonance Spectroscopy - instrumentation
Microfluidics
Miniature
NMR spectroscopy
Nuclear magnetic resonance
Nuclear magnetic resonance spectroscopy
Radio frequency
Sensitivity and Specificity
Spectra
Spectroscopy
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Summary:The philosophy of miniature total analysis systems (/spl mu/-TAS) hinges on the multiple chemical processing steps and the means of analyzing their results on the same miniaturized system. We have constructed chip-based capillary electrophoresis (CE) devices equipped with an integrated planar radio-frequency detector coil used for nuclear magnetic resonance spectroscopy (NMR). Separations were accomplished in the devices, but satisfactory NMR spectra could only be obtained from samples of high concentration. The relative sensitivity is explained and the scaling law dichotomy of CE and NMR explored.
ISSN:0018-9294
1558-2531
DOI:10.1109/10.817611