Contemporary activity of colistin and polymyxin B against a worldwide collection of Gramnegative pathogens: results from the SENTRY Antimicrobial Surveillance Program (2006-09)

To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40 625 Gram-negative bacilli. Antimicrobial susceptibility testing was performed and interpreted using the CLSI broth microdilution method except fo...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2011-09, Vol.66 (9), p.2070
Main Authors: Gales, Ana C, Jones, Ronald N, Sader, Hélio S
Format: Article
Language:English
Subjects:
Drug resistance
Gram-negative bacteria
Surveillance
Online Access:Get full text
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Summary:To comparatively evaluate the antimicrobial activities of colistin and polymyxin B with those of other antimicrobials against a worldwide collection of 40 625 Gram-negative bacilli. Antimicrobial susceptibility testing was performed and interpreted using the CLSI broth microdilution method except for colistin against Enterobacteriaceae. The polymyxins showed potent in vitro activities (MIC^sub 90^, ≤0.5-1 mg/L) against this large collection of clinical isolates, with very low resistance rates (
ISSN:0305-7453
1460-2091