Increased number of microRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction

MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as...

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Bibliographic Details
Published in:Molecular biology and evolution 2011-09, Vol.28 (9), p.2421-2424
Main Authors: Felekkis, Kyriakos, Voskarides, Konstantinos, Dweep, Harsh, Sticht, Carsten, Gretz, Norbert, Deltas, Constantinos
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Binding sites
Computational Biology
Databases, Genetic
DNA Copy Number Variations - genetics
Evolution, Molecular
Gene expression
Gene Expression Regulation
Genetics
Genome, Human
Humans
MicroRNAs - genetics
Molecular biology
Ribonucleic acid
RNA
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Summary:MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity.
ISSN:0737-4038
1537-1719
DOI:10.1093/molbev/msr078