Effect of palm oil carotene on breat cancer tumorigenicity in nude mice

Biological therapies are new additions to breast cancer treatment. Among biological compounds, β‐carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor‐alpha production by macrophages. The objective of this s...

Full description

Saved in:
Bibliographic Details
Published in:Lipids 2002-06, Vol.37 (6), p.557-560
Main Authors: Nesaretnam, Kalanithi, Radhakrishnan, Ammu, Selvaduray, Kanga Rani, Reimann, Karin, Pailoor, Jayalakshmi, Razak, Ghazali, Mahmood, Mina Mustafa, Dahliwal, Jasbir Singh
Format: Article
Language:English
Subjects:
Breast cancer
Immune system
Immunology
Lymphocytes
Palm oil
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biological therapies are new additions to breast cancer treatment. Among biological compounds, β‐carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor‐alpha production by macrophages. The objective of this study was to investigate the effect of palm carotene supplementation on the tumorigenicity of MCF‐7 human breast cancer cells injected into athymic nude mice and to explore the mechanism by which palm carotenes suppress tumorigenesis. Forty‐eight 4‐wk‐old mice were injected with 1×106 MCF‐7 cells into their mammary fat pad. The experimental group was supplemented with palm carotene whereas the control group was not. Significant differences were observed in tumor incidence (P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-002-0932-0