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The important role of glycine N-methyltransferase in the carcinogenesis and progression of prostate cancer
Glycine N-methyltransferase ( GNMT ) has a role in the metabolism of methionine as well as in gluconeogenesis. It has recently been reported that the GNMT gene acts as a tumor-susceptible gene. However, little is known about the specific function of GNMT in carcinogenesis and malignant progression....
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Published in: | Modern pathology 2011-09, Vol.24 (9), p.1272-1280 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Glycine N-methyltransferase
(
GNMT
) has a role in the metabolism of methionine as well as in gluconeogenesis. It has recently been reported that the
GNMT
gene acts as a tumor-susceptible gene. However, little is known about the specific function of
GNMT
in carcinogenesis and malignant progression. To better our understanding of the function of
GNMT
in prostate cancer, we used siRNAs to examine the effects of
GNMT
knockdown on cell proliferation and the cell cycle. In addition, the relation between immunohistochemical
GNMT
expression and clinicopathologic parameters was investigated in 148 prostate cancer tissues. Here, we show that siRNA-mediated
GNMT
knockdown results in an inhibition of proliferation, and induces G1 arrest and apoptosis in prostate cancer cell lines. Moreover, high cytoplasmic
GNMT
expression was also correlated with a higher Gleason score (
P |
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ISSN: | 0893-3952 1530-0285 |
DOI: | 10.1038/modpathol.2011.76 |