Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii

A case of Saccharomyces fungemia in an 8-month-old baby affected by acute myeloid leukemia while receiving intensive chemotherapy is reported. The patient was receiving prophylaxis treatment with Saccharomyces boulardii capsules (Codex) to prevent diarrhea, which is commonly associated with this typ...

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Bibliographic Details
Published in:Supportive care in cancer 2000-11, Vol.8 (6), p.504-505
Main Authors: CESARO, Simone, CHINELLO, Pierangelo, ROSSI, Lucia, ZANESCO, Luigi
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents - adverse effects
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Chemotherapy
Cisplatin - adverse effects
Diarrhea - chemically induced
Diarrhea - prevention & control
Drug toxicity and drugs side effects treatment
Etoposide - adverse effects
Fungemia - diagnosis
Fungemia - etiology
Humans
Ifosfamide - adverse effects
Immunocompromised Host
Infant
Leukemia, Myeloid - complications
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - immunology
Medical sciences
Miscellaneous. Antibiotics with multiple activities
Neutropenia - immunology
Pharmacology. Drug treatments
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - isolation & purification
Toxicity: blood
Yeast
Yeast, Dried - adverse effects
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Description
Summary:A case of Saccharomyces fungemia in an 8-month-old baby affected by acute myeloid leukemia while receiving intensive chemotherapy is reported. The patient was receiving prophylaxis treatment with Saccharomyces boulardii capsules (Codex) to prevent diarrhea, which is commonly associated with this type of chemotherapy. Fever spiked just the day after ending the chemotherapy course, and a strain of Saccharomyces cerevisiae was isolated from blood culture although the patient was also receiving antifungal prophylaxis with fluconazole. The patient recovered, though still neutropenic, with amphotericin-B and removal of the central venous catheter. The common biochemical characteristics make it difficult to differentiate between the strain of Saccharomyces cerevisiae and that of Saccharomyces boulardii with routine methods. In other cases, authors demonstrated an identity between the two strains with a more detailed analysis. These reports raise concern about the potential side effects of such biotherapeutic agents.
ISSN:0941-4355
1433-7339
DOI:10.1007/s005200000123