Safety of adenosine pharmacologic stress myocardial perfusion imaging in orthotopic cardiac transplant recipients: a single center experience of 102 transplant patients

Denervation super-sensitivity to adenosine is well described in cardiac transplant (CT) patients particularly early after transplant. The safety and hemodynamic effects of adenosine SPECT (A-SPECT) has not been described in a large series of CT patients. Single center retrospective study of 102 CT p...

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Bibliographic Details
Published in:The International Journal of Cardiovascular Imaging 2011-10, Vol.27 (7), p.1105-1111
Main Authors: Al-Mallah, Mouaz H., Arida, Muhammad, Garcia-Sayan, Enrique, Assal, Chafik, Zegarra, Gino Tapia, Czerska, Barbara, Ananthasubramaniam, Karthik
Format: Article
Language:English
Subjects:
Adenosine - adverse effects
Aged
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - physiopathology
Cardiac Imaging
Cardiology
Case-Control Studies
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - etiology
Coronary Artery Disease - physiopathology
Coronary Circulation
Female
Heart Conduction System - physiopathology
Heart Transplantation - adverse effects
Hemodynamics
Humans
Imaging
Logistic Models
Male
Medicine
Medicine & Public Health
Michigan
Middle Aged
Myocardial Perfusion Imaging - adverse effects
Myocardial Perfusion Imaging - methods
Original Paper
Predictive Value of Tests
Radiography
Radiology
Retrospective Studies
Risk Assessment
Risk Factors
Tomography, Emission-Computed, Single-Photon - adverse effects
Treatment Outcome
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Summary:Denervation super-sensitivity to adenosine is well described in cardiac transplant (CT) patients particularly early after transplant. The safety and hemodynamic effects of adenosine SPECT (A-SPECT) has not been described in a large series of CT patients. Single center retrospective study of 102 CT patients undergoing A-SPECT were compared to an age-gender matched patients in a 2:1 fashion who underwent A-SPECT in the same time period. Multivariate logistic regression model were used to identify independent predictors of advanced AV block. The average time from CT to A-SPECT was 8.5 ± 4.5 years. Average age was 57 years with 80% males. In comparison to the control group, adenosine infusion was associated with a higher incidence of sinus pause (4.9% vs. 0%), 2nd (11.8% vs. 4.9%) and 3rd degree AVB (2.9% vs. 0%) in CT patients (all P  
ISSN:1569-5794
1573-0743
1875-8312
DOI:10.1007/s10554-010-9749-2