Investigation of metabolic paramagnetic centers in the blood of patients with prostate adenocarcinoma prior to and after the plastic orchectomy

Paramagnetic centers in the blood of patients with prostate adenocarcinoma have been studied prior to and after plastic orchectomy by EPR. It has been shown that significant alterations in blood paramagnetic centers occur after the surgery. These alterations point to an improvement of antioxidant pr...

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Bibliographic Details
Published in:Biophysics (Oxford) 2011-08, Vol.56 (4), p.717-721
Main Authors: Kotrikadze, N. G., Khutsishvili, E. G., Chelidze, M. Z., Alibegashvili, M. R., Artsyvadze, K. L., Sanikidze, T. V., Managadze, L. G., Chigogidze, T. G.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Blood
Complex Systems Biophysics
Metabolism
Physics
Physics and Astronomy
Prostate cancer
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Summary:Paramagnetic centers in the blood of patients with prostate adenocarcinoma have been studied prior to and after plastic orchectomy by EPR. It has been shown that significant alterations in blood paramagnetic centers occur after the surgery. These alterations point to an improvement of antioxidant properties of the blood. Specifically, the content of the Fe 3+ -transferrin complexes increased, and the number of inactivated adrenoreceptors, MetHb, and Mn 2+ -containing complexes decreased. It was found that, along with improvement of the antioxidant properties of the blood, a significant decrease in the intensity of lipid peroxidation in the blood of the patients occurs.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350911040129