Loading…

Randomized double blind prospective trial of active management of the third stage of labor

Introduction: To determine if timing and mode of administration of prophylactic oxytocin influences duration of the third stage of labor, amount of blood loss, and incidence of third stage complications. Material and methods: A randomized double-blind prospective trial in singleton vaginal deliverie...

Full description

Saved in:
Bibliographic Details
Published in:Archives of medical science 2008-03, Vol.4 (1), p.79
Main Authors: Tharakan, Tessie, Jha, Jayanti
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 1
container_start_page 79
container_title Archives of medical science
container_volume 4
creator Tharakan, Tessie
Jha, Jayanti
description Introduction: To determine if timing and mode of administration of prophylactic oxytocin influences duration of the third stage of labor, amount of blood loss, and incidence of third stage complications. Material and methods: A randomized double-blind prospective trial in singleton vaginal deliveries comparing oxytocin intravenous injection after infant delivery versus infusion after placental delivery. Vials of medication oxytocin/saline were prepared by the hospital pharmacy. Results were analyzed after study completion, using the Student's t test. Results: Ninety-nine patients were recruited; 64 completed the study, 32 in each group. The study group received oxytocin after second stage. Drop out occurred due to rapid labor, and due to cesarean deliveries. The two groups were comparable for age, parity, gestational age, and birth weight. Mean (± SD) subjectively estimated blood loss (EBL) showed a statistically significant difference (315.53±91.97 vs. 384.38±116.7, p=0.01). Hematocrit drop and duration of third stage showed a trend to be less in the study group. No cases or controls had retained placenta, hypotension, cardiac arrhythmias, or post partum hemorrhage. Conclusions: Intravenous injection of oxytocin after the second stage is safe and effective compared with common practice of oxytocin infusion after placental delivery. Future larger studies may show larger benefits.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_917221090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2567589591</sourcerecordid><originalsourceid>FETCH-LOGICAL-p182t-3f2fcb4f5672365318ac94f3f6959e98c4bd7a5b032374d7e09248432271c7973</originalsourceid><addsrcrecordid>eNotjk9LxDAUxIMouK5-h-C9kLykTd9RFv_BwoLoxcuSNInbpW1qknrw05tlPc3Mj-G9uSAr3mJTIa_5ZfFKyIojwDW5SenImCyEr8jnm55sGPtfZ6kNixkcNUM_WTrHkGbX5f7H0Rx7PdDgqT7nUU_6y41uyieYD6Vx6KOlKRd8QoM2Id6SK6-H5O7-dU0-nh7fNy_Vdvf8unnYVjNvIVfCg--M9HWjQDS14K3uUHrhG6zRYdtJY5WuDRMglLTKMQTZSgGgeKdQiTW5P98tk78Xl_L-GJY4lZd75AqAM2TiD4EWTqY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>917221090</pqid></control><display><type>article</type><title>Randomized double blind prospective trial of active management of the third stage of labor</title><source>ProQuest - Publicly Available Content Database</source><creator>Tharakan, Tessie ; Jha, Jayanti</creator><creatorcontrib>Tharakan, Tessie ; Jha, Jayanti</creatorcontrib><description>Introduction: To determine if timing and mode of administration of prophylactic oxytocin influences duration of the third stage of labor, amount of blood loss, and incidence of third stage complications. Material and methods: A randomized double-blind prospective trial in singleton vaginal deliveries comparing oxytocin intravenous injection after infant delivery versus infusion after placental delivery. Vials of medication oxytocin/saline were prepared by the hospital pharmacy. Results were analyzed after study completion, using the Student's t test. Results: Ninety-nine patients were recruited; 64 completed the study, 32 in each group. The study group received oxytocin after second stage. Drop out occurred due to rapid labor, and due to cesarean deliveries. The two groups were comparable for age, parity, gestational age, and birth weight. Mean (± SD) subjectively estimated blood loss (EBL) showed a statistically significant difference (315.53±91.97 vs. 384.38±116.7, p=0.01). Hematocrit drop and duration of third stage showed a trend to be less in the study group. No cases or controls had retained placenta, hypotension, cardiac arrhythmias, or post partum hemorrhage. Conclusions: Intravenous injection of oxytocin after the second stage is safe and effective compared with common practice of oxytocin infusion after placental delivery. Future larger studies may show larger benefits.</description><identifier>ISSN: 1734-1922</identifier><identifier>EISSN: 1896-9151</identifier><language>eng</language><publisher>Poznan: Termedia Publishing House</publisher><ispartof>Archives of medical science, 2008-03, Vol.4 (1), p.79</ispartof><rights>Copyright Termedia Publishing House 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/917221090/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/917221090?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,37012,44590,75126</link.rule.ids></links><search><creatorcontrib>Tharakan, Tessie</creatorcontrib><creatorcontrib>Jha, Jayanti</creatorcontrib><title>Randomized double blind prospective trial of active management of the third stage of labor</title><title>Archives of medical science</title><description>Introduction: To determine if timing and mode of administration of prophylactic oxytocin influences duration of the third stage of labor, amount of blood loss, and incidence of third stage complications. Material and methods: A randomized double-blind prospective trial in singleton vaginal deliveries comparing oxytocin intravenous injection after infant delivery versus infusion after placental delivery. Vials of medication oxytocin/saline were prepared by the hospital pharmacy. Results were analyzed after study completion, using the Student's t test. Results: Ninety-nine patients were recruited; 64 completed the study, 32 in each group. The study group received oxytocin after second stage. Drop out occurred due to rapid labor, and due to cesarean deliveries. The two groups were comparable for age, parity, gestational age, and birth weight. Mean (± SD) subjectively estimated blood loss (EBL) showed a statistically significant difference (315.53±91.97 vs. 384.38±116.7, p=0.01). Hematocrit drop and duration of third stage showed a trend to be less in the study group. No cases or controls had retained placenta, hypotension, cardiac arrhythmias, or post partum hemorrhage. Conclusions: Intravenous injection of oxytocin after the second stage is safe and effective compared with common practice of oxytocin infusion after placental delivery. Future larger studies may show larger benefits.</description><issn>1734-1922</issn><issn>1896-9151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNotjk9LxDAUxIMouK5-h-C9kLykTd9RFv_BwoLoxcuSNInbpW1qknrw05tlPc3Mj-G9uSAr3mJTIa_5ZfFKyIojwDW5SenImCyEr8jnm55sGPtfZ6kNixkcNUM_WTrHkGbX5f7H0Rx7PdDgqT7nUU_6y41uyieYD6Vx6KOlKRd8QoM2Id6SK6-H5O7-dU0-nh7fNy_Vdvf8unnYVjNvIVfCg--M9HWjQDS14K3uUHrhG6zRYdtJY5WuDRMglLTKMQTZSgGgeKdQiTW5P98tk78Xl_L-GJY4lZd75AqAM2TiD4EWTqY</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Tharakan, Tessie</creator><creator>Jha, Jayanti</creator><general>Termedia Publishing House</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20080301</creationdate><title>Randomized double blind prospective trial of active management of the third stage of labor</title><author>Tharakan, Tessie ; Jha, Jayanti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p182t-3f2fcb4f5672365318ac94f3f6959e98c4bd7a5b032374d7e09248432271c7973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tharakan, Tessie</creatorcontrib><creatorcontrib>Jha, Jayanti</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Archives of medical science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tharakan, Tessie</au><au>Jha, Jayanti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized double blind prospective trial of active management of the third stage of labor</atitle><jtitle>Archives of medical science</jtitle><date>2008-03-01</date><risdate>2008</risdate><volume>4</volume><issue>1</issue><spage>79</spage><pages>79-</pages><issn>1734-1922</issn><eissn>1896-9151</eissn><abstract>Introduction: To determine if timing and mode of administration of prophylactic oxytocin influences duration of the third stage of labor, amount of blood loss, and incidence of third stage complications. Material and methods: A randomized double-blind prospective trial in singleton vaginal deliveries comparing oxytocin intravenous injection after infant delivery versus infusion after placental delivery. Vials of medication oxytocin/saline were prepared by the hospital pharmacy. Results were analyzed after study completion, using the Student's t test. Results: Ninety-nine patients were recruited; 64 completed the study, 32 in each group. The study group received oxytocin after second stage. Drop out occurred due to rapid labor, and due to cesarean deliveries. The two groups were comparable for age, parity, gestational age, and birth weight. Mean (± SD) subjectively estimated blood loss (EBL) showed a statistically significant difference (315.53±91.97 vs. 384.38±116.7, p=0.01). Hematocrit drop and duration of third stage showed a trend to be less in the study group. No cases or controls had retained placenta, hypotension, cardiac arrhythmias, or post partum hemorrhage. Conclusions: Intravenous injection of oxytocin after the second stage is safe and effective compared with common practice of oxytocin infusion after placental delivery. Future larger studies may show larger benefits.</abstract><cop>Poznan</cop><pub>Termedia Publishing House</pub><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1734-1922
ispartof Archives of medical science, 2008-03, Vol.4 (1), p.79
issn 1734-1922
1896-9151
language eng
recordid cdi_proquest_journals_917221090
source ProQuest - Publicly Available Content Database
title Randomized double blind prospective trial of active management of the third stage of labor
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A31%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Randomized%20double%20blind%20prospective%20trial%20of%20active%20management%20of%20the%20third%20stage%20of%20labor&rft.jtitle=Archives%20of%20medical%20science&rft.au=Tharakan,%20Tessie&rft.date=2008-03-01&rft.volume=4&rft.issue=1&rft.spage=79&rft.pages=79-&rft.issn=1734-1922&rft.eissn=1896-9151&rft_id=info:doi/&rft_dat=%3Cproquest%3E2567589591%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p182t-3f2fcb4f5672365318ac94f3f6959e98c4bd7a5b032374d7e09248432271c7973%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=917221090&rft_id=info:pmid/&rfr_iscdi=true