Extramedullary relapse of acute myelogenous leukaemia due to chronic GVHD as a complication of allogeneic HSCT

We report a 41-year-old man with AML and unfavourable complex chromosome abnormalities who was treated with alloHSCT in first complete remission. Two years after transplant due to limited chronic GVHD this patient presented painful oedema around the left wrist. Histology of the soft tissue tumour, f...

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Bibliographic Details
Published in:Archives of medical science 2009-12, Vol.5 (4), p.656
Main Authors: Nasilowska-Adamska, Barbara, Tomaszewska, Agnieszka, Halaburda, Kazimierz, Prochorec-Sobieszek, Monika, Strzelczyk, Piotr, Wierzbowska, Agnieszka, Smolarczyk-Wodzynska, Justyna, Pienkowska-Grela, Barbara, Marianska, Bozena
Format: Article
Language:English
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Summary:We report a 41-year-old man with AML and unfavourable complex chromosome abnormalities who was treated with alloHSCT in first complete remission. Two years after transplant due to limited chronic GVHD this patient presented painful oedema around the left wrist. Histology of the soft tissue tumour, found in CT scanning of this wrist, revealed isolated extramedullary (EM) leukaemia relapse. He was treated with surgery, local radiotherapy and systemic chemotherapy. This case suggests that the anti-leukaemic effect of GVHD in EM sites might not be effective. Moreover, there is a possibility that GVHD predisposes to isolated EM relapses of leukaemia.
ISSN:1734-1922
1896-9151