Quantitative I-123 mIBG SPECT in differentiating abnormal and normal mIBG myocardial uptake

The purpose of this study was to evaluate global quantitation of cardiac uptake on I-123 mIBG SPECT. The study included a pilot group of 67 subjects and a validation group of 1,051 subjects. SPECT images were reconstructed by filtered backprojection, ordered subsets expectation maximization, and dec...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2012-02, Vol.19 (1), p.92-99
Main Authors: Chen, Ji, Folks, Russell D., Verdes, Liudmila, Manatunga, Daya N., Jacobson, Arnold F., Garcia, Ernest V.
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - pharmacokinetics
Aged
Algorithms
Cardiology
Diagnosis, Differential
Female
Heart - diagnostic imaging
heart failure
Heart Failure - diagnostic imaging
Heart Failure - metabolism
Humans
I-123 mIBG
Image Interpretation, Computer-Assisted - methods
Imaging
Male
Medicine
Medicine & Public Health
Myocardium - metabolism
Nuclear Medicine
Original Article
Pilot Projects
Radiology
Radiopharmaceuticals - pharmacokinetics
Reference Values
Reproducibility of Results
Sensitivity and Specificity
SPECT
Sympathetic nervous system
Tissue Distribution
Tomography, Emission-Computed, Single-Photon - methods
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Summary:The purpose of this study was to evaluate global quantitation of cardiac uptake on I-123 mIBG SPECT. The study included a pilot group of 67 subjects and a validation group of 1,051 subjects. SPECT images were reconstructed by filtered backprojection, ordered subsets expectation maximization, and deconvolution of septal penetration, respectively. SPECT heart-to-mediastinum ratio (H/M) was calculated by comparing the mean counts between heart and mediastinum volumes of interest drawn on transaxial images. Receiver operating characteristic (ROC) analysis was used to assess the capability of each SPECT method to differentiate the heart disease subjects from controls in comparison with that of the planar H/M. In the validation group, the areas under the ROC curves were not significantly different between the SPECT and planar H/M. Order subsets expectation maximization had significantly larger area under the ROC curve than the other two SPECT methods. H/M obtained from I-123 mIBG SPECT was equivalent to the planar H/M for differentiating between subjects with normal and abnormal mIBG uptake. Global quantification of cardiac I-123 mIBG SPECT may represent a viable alternative to the planar H/M.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-011-9438-0