Selective adenosine agonists and myocardial perfusion imaging

Selective adenosine receptor agonists have several advantages for use as stress agents in conjunction with myocardial perfusion imaging compared to the non selective agents such as adenosine and dipyridamole. This review will summarize the pre-clinical and clinical data on the selective adenosine ag...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nuclear cardiology 2012-02, Vol.19 (1), p.126-141
Main Authors: Zoghbi, Gilbert J., Iskandrian, Ami E.
Format: Article
Language:English
Subjects:
apadenoson
binodenoson
Cardiology
Exercise Test - methods
Humans
Image Enhancement - methods
Imaging
Medicine
Medicine & Public Health
Myocardial perfusion imaging
Myocardial Perfusion Imaging - methods
Nuclear Medicine
Purinergic P1 Receptor Agonists
Radiology
regadenoson
Review Article
selective adenosine agonists
Tomography, Emission-Computed - methods
Vasodilator Agents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Selective adenosine receptor agonists have several advantages for use as stress agents in conjunction with myocardial perfusion imaging compared to the non selective agents such as adenosine and dipyridamole. This review will summarize the pre-clinical and clinical data on the selective adenosine agonist stress agents regadenoson (Lexiscan®), binodenoson (CorVue™) and apadenoson (Stedivaze™) that have been studied so far with focus on regadenoson that has the most clinical data published so far. The article will review the adenosine receptor types and properties. It will also review the various attributes of the selective adenosine agonists including their pharmacology, pharmacokinetics and pharmacodynamics, their coronary vasodilatory and hemodynamic effects, their safety and side effects, their interactions with other drugs and their use with myocardial perfusion imaging. The landmark trials of the selective adenosine agonists will be reviewed as well as their use in special patient populations undergoing stress myocardial perfusion imaging.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-011-9474-9