Cardiac troponin T as a marker of myocardial damage caused by antineoplastic drugs in rabbits

Anthracycline derivatives are among the most effective antineoplastic drugs but their therapeutic use is limited by their adverse effects. The cardiac side-effects of antineoplastic drugs were investigated in rabbits in vivo from the viewpoint of release of cardiac troponin T (cTnT) measured by Elec...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1999, Vol.125 (5), p.268-274
Main Authors: ADAMCOVA, M, GERSL, V, HRDINA, R, MELKA, M, MAZUROVA, Y, VAVROVA, J, PALICKA, V, KOKSTEIN, Z
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - adverse effects
Antineoplastic agents
Antineoplastic Agents - adverse effects
Biological and medical sciences
Biomarkers - analysis
Cardiomyopathies - chemically induced
Cardiomyopathies - metabolism
Chemotherapy
Daunorubicin - adverse effects
Drug Administration Schedule
Ethanolamines - adverse effects
Infusions, Intravenous
Isoquinolines - adverse effects
Male
Medical sciences
Myocardium - metabolism
Pharmacology. Drug treatments
Rabbits
Troponin T - metabolism
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Summary:Anthracycline derivatives are among the most effective antineoplastic drugs but their therapeutic use is limited by their adverse effects. The cardiac side-effects of antineoplastic drugs were investigated in rabbits in vivo from the viewpoint of release of cardiac troponin T (cTnT) measured by Elecsys Troponin T STAT immunoassay (Boehringer Mannheim, Germany). No increase in cTnT was found following administration of a single dose of daunorubicin (3 mg/kg i.v., n = 4). During development of daunorubicin-induced cardiomyopathy (daunorubicin 3 mg/kg i.v., once a week; maximum nine administrations, n = 7), the levels of cTnT were within the physiological range (i.e. cTnT
ISSN:0171-5216
1432-1335
DOI:10.1007/s004320050273