A comparison of midazolam, alfentanil and propofol for sedation in oupatient intraocular surgery

• Published in: Canadian journal of anesthesia 2000-03, Vol.47 (3), p.211-214
• Main Authors: MCHARDY, F. E, FORTIER, J, CHUNG, F, KRISHNATHAS, A, MARSHALL, S. I
• Format: Article
• Language: English
• Subjects: Anesthesia; Anesthesia depending on type of surgery; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood pressure; Hypnotics. Sedatives; Medical sciences; Neuropharmacology; Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics; Pain; Patient satisfaction; Pharmacology. Drug treatments; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology
• ISSN: 0832-610X; 1496-8975
• DOI: 10.1007/BF03018914

Purpose: To determine the ideal sedative regimen for intraocular surgery under peribulbar or retrobulbar block. The addition of alfentanil and or propofol to midazolam was evaluated with regard to hemodynamic variables, respiratory rate, pain, anxiety, sedation, postoperative recovery and patient satisfaction.Methods: Eighty two patients aged between 50 and 85 were recruited into this prospective, randomised, double blind study. Patients, in four groups, received 0.015 mg·kg−1 midazolam, 5 µg·kg−1 alfentanil and 0.15 mg·kg−1 propofol; 0.015 mg·kg−1 midazolam and 0.15 mg·kg−1 propofol; 0.015 mg·kg−1 midazolam and 5 µg·kg−1 alfentanil or 0.015 mg·kg−1 midazolam alone. Blood pressure, heart rate, respiratory rate, pain, anxiety and sedation scores were measured. Times to discharge from the Post Anesthesia Care Unit (PACU) and Day Surgery Unit (DSU) were documented. A 24 hr telephone interview was carried out to determine patient satisfaction.Results: Systolic blood pressure of patients in groups that had received alfentanil was 6% lower than that of patients who had not (P