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Use of nanoparticles for studying the conformations of submembrane hemoglobin

The advantages and specific features of integrated application of atomic force microscopy, laser interference microscopy, and Raman microscopy in the study of erythrocytes are discussed. For successful application of Raman microscopy in the surface-enhanced mode, use was made of silver colloids. The...

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Bibliographic Details
Published in:Biophysics (Oxford) 2011-12, Vol.56 (6), p.1069-1073
Main Authors: Maksimov, G. V., Brazhe, N. A., Yusipovich, A. I., Parshina, E. Yu, Rodnenkov, O. V., Rubin, A. B., Levin, G. G., Bykov, V. A.
Format: Article
Language:English
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Summary:The advantages and specific features of integrated application of atomic force microscopy, laser interference microscopy, and Raman microscopy in the study of erythrocytes are discussed. For successful application of Raman microscopy in the surface-enhanced mode, use was made of silver colloids. The dependence of the enhancement of Raman signals on silver nanoparticle size is demonstrated. The use of developed methods in clinical diagnostics is discussed.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350911060121