Advanced glycation end products in myocardial reperfusion injury

• Published in: Heart and vessels 2012-03, Vol.27 (2), p.208-215
• Main Authors: Celec, Peter, Hodosy, Július, Jáni, Peter, Janega, Pavol, Kúdela, Matúš, Kalousová, Marta, Holzerová, Johana, Parrák, Vojtech, Halčák, Lukáč, Zima, Tomáš, Braun, Martin, Pecháň, Ivan, Murín, Ján, Šebeková, Katarína
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Arginine - analogs & derivatives; Arginine - blood; Biochemistry; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiac Surgical Procedures - adverse effects; Cardiology; Cardiovascular disease; Disease Models, Animal; Fasting - blood; Female; Glycation End Products, Advanced - blood; Heart attacks; Humans; Lysine - analogs & derivatives; Lysine - blood; Male; Medicine; Medicine & Public Health; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - complications; Myocardial Infarction - drug therapy; Myocardial Infarction - immunology; Myocardial Reperfusion Injury - etiology; Myocardial Reperfusion Injury - immunology; Myocardial Reperfusion Injury - metabolism; Neopterin - blood; Original Article; Rabbits; Stroke Volume; Thrombolytic Therapy - adverse effects; Time Factors; Treatment Outcome; Vascular Surgery; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - surgery; Ventricular Function, Left; Young Adult
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-011-0147-z

Advanced glycation end products (AGEs) are associated with cardiovascular diseases. Whether the AGE levels change during myocardial reperfusion injury is currently unknown. The aim of our study was to investigate the dynamics of AGEs in myocardial reperfusion injury and to discuss potential reasons for these changes. The dynamics of AGEs, pentosidine and neopterin in the plasma of patients with acute myocardial infarction (AMI) treated using thrombolysis ( n  = 40) were analyzed. In addition, AGEs were measured in patients with open heart surgery ( n  = 12) and rabbits with induced AMI ( n  = 9). In all three studies of myocardial reperfusion injury, a significant decrease of AGEs was observed (by 26 ± 19% in patients with AMI, by 23 ± 14% in patients with open heart surgery and by 39 ± 10% in rabbits with AMI within 1 day of reperfusion; p