Mast cell stabilising activity of various subfractions of leaves of Vitex Negundo

To evaluate anti-asthmatic, anti-inflammatory, and anti-allergic activity of various subfractions of ethyl acetate fraction of leaves of Vitex negundo. Ethyl acetate fraction (EAF) of leaves of V. negundo was further subfractionated into NaOH fraction, acetone fraction, and chloroform fraction to se...

Full description

Saved in:
Bibliographic Details
Published in:International journal of green pharmacy 2011, Vol.5 (4), p.273
Main Authors: Patel, JigneshI, Deshpande, ShrikalpS
Format: Article
Language:English
Subjects:
Asthma
Cells
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate anti-asthmatic, anti-inflammatory, and anti-allergic activity of various subfractions of ethyl acetate fraction of leaves of Vitex negundo. Ethyl acetate fraction (EAF) of leaves of V. negundo was further subfractionated into NaOH fraction, acetone fraction, and chloroform fraction to separate chemical constituents present in EAF using thin layer chromatography technique and different solvent systems. The stabilisation potential of the various subfractions of EAF of leaves of V. negundo against mast cell degranulation was studied on isolated mesentery of rat by exposure to compound 48/80. Dexamethasone (5 mg/kg) was used as a reference standard. AF of EAF of leaves of V. negundo (500 μg/ml) showed significant protection of rat mesenteric mast cells from disruption caused by compound 48/80. This study concluded that AF of EAF of leaves of V. negundo shows mast cell stabilising activity. It may be useful as anti-asthmatic, anti-inflammatory, and anti-allergic agent.
ISSN:0973-8258
1998-4103
DOI:10.4103/0973-8258.94346