Surgical resection of subependymal giant cell astrocytomas (SEGAs) and changes in SEGA-related conditions: a US national claims database study

Abstract Objectives: To compare the prevalence rates of clinical conditions related to subependymal giant cell astrocytomas (SEGAs) before and after SEGA surgery among patients with tuberous sclerosis complex (TSC). Methods: Based on three US national claims databases, we analyzed and compared the p...

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Bibliographic Details
Published in:Current medical research and opinion 2012-04, Vol.28 (4), p.651-656
Main Authors: Sun, Peter, Krueger, Darcy, Liu, Jamae, Guo, Amy, Rogerio, Jaqueline, Kohrman, Michael
Format: Article
Language:English
Subjects:
Astrocytoma - epidemiology
Astrocytoma - surgery
Bootstrapping method
Brain Neoplasms - epidemiology
Brain Neoplasms - surgery
Clinical effectiveness
Databases, Factual
Female
Humans
Insurance Claim Review
Male
Repeated measures analysis
SEGA-related conditions
Subependymal giant cell astrocytoma
Surgical resection
Time Factors
Tuberous Sclerosis - epidemiology
Tuberous Sclerosis - surgery
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Summary:Abstract Objectives: To compare the prevalence rates of clinical conditions related to subependymal giant cell astrocytomas (SEGAs) before and after SEGA surgery among patients with tuberous sclerosis complex (TSC). Methods: Based on three US national claims databases, we analyzed and compared the prevalence rates of 21 SEGA-related conditions (including seizures, hydrocephalus, headaches and stroke or hemiparesis) in the six months preceding surgery with the rates in the second through sixth post-surgery months and in the seventh through twelfth post-surgery months among TSC patients who underwent SEGA surgery during 2000-2009. Repeated measures analysis with a bootstrapping method was used to assess the surgery impact. Results: Patients (N = 47) had a mean age of 11.5 years at their first SEGA surgery, and 66% were male. Compared with the six months preceding surgery, the post-surgery prevalence rates increased by 23-26% for seizures, 21-26% for hydrocephalus, 17-19% for headache and 6-9% for stroke or hemiparesis (all p 
ISSN:0300-7995
1473-4877
DOI:10.1185/03007995.2012.658908