Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza

Summary Post-influenza bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness. However, despite much interest in influenza and its complications in recent years, good clinical trial data to inform clinicians in their assessm...

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Bibliographic Details
Published in:International journal of infectious diseases 2012-05, Vol.16 (5), p.e321-e331
Main Authors: Metersky, Mark L, Masterton, Robert G, Lode, Hartmut, File, Thomas M, Babinchak, Timothy
Format: Article
Language:English
Subjects:
Age Factors
Animals
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antiviral agents
Antiviral Agents - therapeutic use
Humans
Infectious Disease
Influenza A virus
Influenza, human
Influenza, Human - complications
Influenza, Human - drug therapy
Influenza, Human - mortality
Pandemics
Pneumonia, bacterial
Pneumonia, Bacterial - drug therapy
Pneumonia, Bacterial - etiology
Pneumonia, Bacterial - microbiology
Pneumonia, Bacterial - mortality
Practice Guidelines as Topic
Pulmonary/Respiratory
Risk Factors
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Summary:Summary Post-influenza bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness. However, despite much interest in influenza and its complications in recent years, good clinical trial data to inform clinicians in their assessment of treatment options are scant. This paucity of evidence needs to be addressed urgently in order to improve guidance on the management of post-influenza bacterial pneumonia. The objectives of the current article are to evaluate the emergence of the 2009 H1N1 influenza pandemic and use this information as background for an in-depth review of the epidemiology of bacterial pneumonia complicating influenza, to review the bacterial pathogens most likely to be associated with post-influenza bacterial pneumonia, and to discuss treatment considerations in these patients. When determining optimal management approaches, both antiviral and antibacterial agents should be considered, and their selection should be based upon a clear understanding of how their mechanisms of action intervene in the pathogenesis of post-influenza acute bacterial pneumonia.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2012.01.003