Short- and Long-Term Changes in Gastric Morphology and Histopathology Following Sleeve Gastrectomy in Diet-Induced Obese Rats

Background Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of morbid obesity. The aim of the study was to analyze gastric morphology and histology at two different time points after SG in rats. Methods Thirty-five male Wistar rats were fed ad libitum duri...

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Bibliographic Details
Published in:Obesity surgery 2012-04, Vol.22 (4), p.634-640
Main Authors: Martín, Marina, Burrell, María A., Gómez-Ambrosi, Javier, Valentí, Víctor, Bueno, Álvaro, Ramírez, Beatriz, Becerril, Sara, Lancha, Andoni, del Sol Calderón, Pablo, Méndez-Giménez, Leire, Catalán, Victoria, Rodríguez, Amaia, Fernández, Secundino, Muñoz-Navas, Miguel, Cienfuegos, Javier A., Frühbeck, Gema
Format: Article
Language:English
Subjects:
Animal Research
Animals
Diet, High-Fat
Disease Models, Animal
Gastrectomy - methods
Gastrointestinal surgery
Histology
Immunohistochemistry
Male
Medicine
Medicine & Public Health
Morphology
Obesity
Obesity, Morbid - etiology
Obesity, Morbid - pathology
Obesity, Morbid - surgery
Rats
Rats, Wistar
Rodents
Stomach - pathology
Stomach - surgery
Surgery
Time Factors
Weight Loss
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Summary:Background Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of morbid obesity. The aim of the study was to analyze gastric morphology and histology at two different time points after SG in rats. Methods Thirty-five male Wistar rats were fed ad libitum during 3 months on a high-fat diet to induce obesity. Subsequently, 25 diet-induced obese rats underwent either SG ( n  = 12) or a sham operation ( n  = 13). The remaining ten obese animals encompassed the nonoperated control group (Co). Four weeks postoperatively, 15 rats ( n  = 5 rats/experimental group) were sacrificed, while the remaining 20 rats were sacrificed after 16 weeks (animals/group; Co = 5, sham = 8, SG = 7) to compare the gastric morphological and histopathological changes over time. Body weight and food intake were regularly recorded. Results For both time periods, the Co groups exhibited the highest body weight, while the rats undergoing the SG showed the lowest weight gain ( P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-012-0606-3