Understanding Disintegrant Action by Visualization

The aim of this study was to utilize high-speed video imaging for understanding the disintegrability of compacts and disintegrant action upon wetting. High-speed video imaging was used to visualize the disintegration of compacts and effect of wetting on free disintegrant particles. Acquired images w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2012-06, Vol.101 (6), p.2155-2164
Main Authors: Desai, Parind Mahendrakumar, Liew, Celine Valeria, Heng, Paul Wan Sia
Format: Article
Language:English
Subjects:
Biological and medical sciences
compaction
compression
crospovidone
disintegration
Excipients
General pharmacology
high-speed video imaging
image analysis
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
strain recovery
Wettability
wetting
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Summary:The aim of this study was to utilize high-speed video imaging for understanding the disintegrability of compacts and disintegrant action upon wetting. High-speed video imaging was used to visualize the disintegration of compacts and effect of wetting on free disintegrant particles. Acquired images were processed using MATLAB, and changes in the compact area and instantaneous motion of compacted particles on contact with water were analyzed. The capillary action of compacts was also determined for various disintegrants. Finally, the breakdown behavior of compacts prepared with selected disintegrants was analyzed at different compression forces to evaluate recovery of compaction strain. Water-insoluble inert diluent, dicalcium phosphate, was used as a comparator. The results from this visualization study provided an in-depth understanding of the disintegrant behavior of free and compacted disintegrant particles upon wetting. The mechanisms of swelling, capillary action, disruption of particle–particle bonds and strain recovery were successfully monitored by video imaging. The disintegration of compacts containing crospovidone appeared to be less influenced by swelling or wicking action. The influence of compression force on the disintegration of selected disintegrants confirmed that strain recovery is the dominant mechanism for the disintegrant action of crospovidone. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:2155–2164, 2012
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.23119