EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report

Summary Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herei...

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Bibliographic Details
Published in:Human pathology 2012-05, Vol.43 (5), p.764-768
Main Authors: Flucke, Uta, MD, Mentzel, Thomas, MD, Verdijk, Marian A., MSc, Slootweg, Pieter J., MD, DMD, PhD, Creytens, David H., MD, Suurmeijer, Albert J.H., MD, PhD, Tops, Bastiaan B.J., PhD
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cancer
EWSR1-ATF1 fusion
Genes
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myoepithelial tumor
Myoepithelioma - genetics
Myoepithelioma - pathology
Oncogene Proteins, Fusion - genetics
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pelvic Neoplasms - genetics
Pelvic Neoplasms - pathology
Proteins
Soft tissue
Tumors
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Summary:Summary Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1 . In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2011.08.004