Polish artificial heart program

Despite significant advances in the development of artificial heart substitutes, anthrombogenic materials and surfaces remain to be the main challenge for implants, which can prevent thrombosis that leads to rejection. The goal of material engineering is essentially to design polymeric materials of...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2012-05, Vol.4 (3), p.322-328
Main Authors: El Fray, Miroslawa, Czugala, Monika
Format: Article
Language:English
Subjects:
Animals
Artificial organs
Biocompatible Materials
Biomaterials
Biomedical materials
Design engineering
Durability
Elastomers
Heart
Heart, Artificial
Humans
Medical materials
Nanomaterials
Nanostructures
Nanotechnology
Poland
Polyester thermoplastic elastomers
Polyurethane
Polyurethane resins
Polyurethanes
Prostheses
Prosthesis Design
Surface properties
Surgery
Surgical equipment
Surgical implants
Thermoplastic elastomers
Thromboembolism
Thrombosis
Tissues
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Summary:Despite significant advances in the development of artificial heart substitutes, anthrombogenic materials and surfaces remain to be the main challenge for implants, which can prevent thrombosis that leads to rejection. The goal of material engineering is essentially to design polymeric materials of high durability and optimal thrombogenicity in mechanical heart prosthesis, being developed recently in a frame of the polish artificial heart program. For these reasons, various surface modifications are being continuously developed for a ‘gold standard’ material, which is a polyurethane (PU) thermoplastic elastomer and they will be shortly reviewed. However, new polymeric materials can meet medical word's attention if they are able to provide similar or better characteristics in term of bulk and surface properties. Specifically, if they will show appropriate surface topography, which is the most influential in determining the response of live tissues toward biomaterials. Nanostructured polyester thermoplastic elastomers of high biodurability as an alternative to PU materials for artificial heart are challenging new materials, and they will be discussed briefly. WIREs Nanomed Nanobiotechnol 2012, 4:322–328. doi: 10.1002/wnan.175 This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.175