Favorable infertility outcomes following anti-tubercular treatment prescribed on the sole basis of a positive polymerase chain reaction test for endometrial tuberculosis

BACKGROUND The endometrial tuberculosis (TB) PCR test is now commonly employed for the diagnosis of female genital TB, a common cause of infertility in India. Although treatment in the absence of demonstrable tubal damage may be of doubtful benefit to fertility, the presence of mycobacterial DNA dem...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2012-05, Vol.27 (5), p.1368-1374
Main Authors: Jindal, U.N., Verma, S., Bala, Y.
Format: Article
Language:English
Subjects:
Adult
Antitubercular Agents - therapeutic use
Biological and medical sciences
Female
Gynecology. Andrology. Obstetrics
Humans
Infertility, Female - drug therapy
Infertility, Female - etiology
Medical sciences
Mycobacterium tuberculosis - genetics
Polymerase Chain Reaction
Pregnancy
Pregnancy Rate
Treatment Outcome
Tuberculosis, Female Genital - complications
Tuberculosis, Female Genital - diagnosis
Tuberculosis, Female Genital - drug therapy
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Summary:BACKGROUND The endometrial tuberculosis (TB) PCR test is now commonly employed for the diagnosis of female genital TB, a common cause of infertility in India. Although treatment in the absence of demonstrable tubal damage may be of doubtful benefit to fertility, the presence of mycobacterial DNA demonstrated by a positive PCR indicates infection by tubercle bacilli causing sub-clinical or latent disease potentially responsible for future clinical manifestations. This study was undertaken to assess the outcome of infertility management following early anti-tubercular treatment (ATT) based only on a positive endometrial TB-PCR test. METHODS This was an intervention study conducted at an IVF center in northern India in 443 infertile women of whom 169 (38.15%) were found to have positive TB-PCR (Group I), while 274 (61.85%) had negative Mycobacterium tuberculosis (MTB)-PCR (Group II). Infertile women of
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/des076