Hemoglobin A1c above Threshold Level is Associated with Decreased β-Cell Function in Overweight Latino Youth

• Published in: The Journal of pediatrics 2012-05, Vol.160 (5), p.751-756
• Main Authors: Toledo-Corral, Claudia M., PhD, MPH, Vargas, Lisa G., MD, Goran, Michael I., PhD, Weigensberg, Marc J., MD
• Format: Article
• Language: English
• Subjects: Adolescent; adolescents; Age Distribution; Biological and medical sciences; body fat; Body Mass Index; childhood obesity; children; Chromatography, High Pressure Liquid - methods; Cohort Studies; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - ethnology; dual-energy X-ray absorptiometry; fasting; Female; females; General aspects; glucose; glucose tolerance; Glucose Tolerance Test; glucose tolerance tests; Glycated Hemoglobin A - analysis; Glycated Hemoglobin A - metabolism; glycohemoglobin; Hispanic Americans - statistics & numerical data; Humans; Incidence; insulin; insulin resistance; Insulin Resistance - physiology; Insulin-Secreting Cells - metabolism; Latinos; Male; males; Medical sciences; Metabolic diseases; noninsulin-dependent diabetes mellitus; Obesity; Overweight - blood; Overweight - ethnology; pathogenesis; Pediatrics; Predictive Value of Tests; Prospective Studies; Reference Values; risk; Risk Assessment; youth
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2011.10.024

Objective To examine whether a hemoglobin A1c (HbA1c)-identified prediabetic state (HbA1c ≥6.0%-6.4%) is associated with decreased insulin sensitivity (SI) and β-cell dysfunction, known factors in the pathogenesis of type 2 diabetes, in an overweight pediatric population. Study design A total of 206 healthy overweight Latino adolescents (124 males and 82 females; mean age, 13.1 ± 2.0 years) were divided into 2 groups: lower risk (n = 179), with HbA1c