Optimal outcomes for liver-dominant metastatic breast cancer with transarterial chemoembolization with drug-eluting beads loaded with doxorubicin

The purpose of this study was to evaluate the efficacy of image-guided delivery of locoregional chemotherapy to breast cancer hepatic metastases using doxorubicin-loaded drug-eluting beads (DEBDOX). An IRB-approved multi-center, prospective, open, non-controlled repeat treatment registry to investig...

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Bibliographic Details
Published in:Breast cancer research and treatment 2012-04, Vol.132 (2), p.753-763
Main Authors: Martin, Robert C. G., Robbins, Ken, Fagés, Joan Falcó, Romero, Francisco Diaz, Rustein, Lisa, Tomalty, Dana, Monaco, Ricardo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Anthracyclines
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - adverse effects
Argentina
Biological and medical sciences
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Brief Report
Cancer
Cancer patients
Cancer research
Cancer therapies
Chemoembolization, Therapeutic - adverse effects
Chemotherapy
Chi-Square Distribution
Disease-Free Survival
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Drug Carriers
Drug delivery
Drug delivery systems
Drug therapy
Female
Gynecology. Andrology. Obstetrics
Humans
Liver
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Mammary gland diseases
Medical sciences
Medicine
Medicine & Public Health
Metastases
Metastasis
Microspheres
Middle Aged
Oncology
Proportional Hazards Models
Prospective Studies
Registries
Spain
Statistical analysis
Stent (Surgery)
Survival
Survival Analysis
Time Factors
Toxicity
Treatment Outcome
Tumors
United States
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Description
Summary:The purpose of this study was to evaluate the efficacy of image-guided delivery of locoregional chemotherapy to breast cancer hepatic metastases using doxorubicin-loaded drug-eluting beads (DEBDOX). An IRB-approved multi-center, prospective, open, non-controlled repeat treatment registry to investigate the safety and efficacy of doxorubicin microspheres in the treatment of patients with unresectable liver metastasis from breast cancer was reviewed. Statistical analysis was performed with differences of P  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-011-1926-z