Antibacterial Compounds from the Mushroom Ganoderma colossum from Nigeria

Three colossolactones (colossolactone E, colossolactone B and 23‐hydroxycolossolactone E) were isolated and characterized from an n‐hexane:dichloromethane (2:7) extract of Ganoderma colossum using chromatographic techniques. The antimicrobial activity of the three compounds was then tested against G...

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Bibliographic Details
Published in:Phytotherapy research 2012-05, Vol.26 (5), p.748-751
Main Authors: Ofodile, L. N, Uma, N, Grayer, R. J, Ogundipe, O. T, Simmonds, M. S. J
Format: Article
Language:English
Subjects:
agar
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibiotics
antimicrobial properties
Bacillus subtilis
Bacillus subtilis - drug effects
bacteria
Biological and medical sciences
chromatography
colossolactones
Ganoderma
Ganoderma - chemistry
General pharmacology
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Microbial Sensitivity Tests
mushrooms
Nigeria
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Pseudomonas syringae
Pseudomonas syringae - drug effects
spectroscopy
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Summary:Three colossolactones (colossolactone E, colossolactone B and 23‐hydroxycolossolactone E) were isolated and characterized from an n‐hexane:dichloromethane (2:7) extract of Ganoderma colossum using chromatographic techniques. The antimicrobial activity of the three compounds was then tested against Gram‐positive and Gram‐negative bacteria. The activity was evaluated by the thin‐layer chromatography agar overlay method. The results showed that colossolactone E and 23‐hydroxycolossolactone E were active against Bacillus subtilis and Pseudomonas syringae. Colossolactone B was not active against the bacteria. Their structures were elucidated by spectroscopic methods. Potency of the compounds against bacteria tested supports the use of this mushroom in therapeutic medicine.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.3598