CDX2 Expression in Columnar Cell Variant of Papillary Thyroid Carcinoma

The columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is a rare subtype of PTC that exhibits morphologic features often described as reminiscent of secretory endometrium or colonic adenomas/adenocarcinomas. CDX2, a nuclear transcription factor, is important for intestinal development. I...

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Bibliographic Details
Published in:American journal of clinical pathology 2012-05, Vol.137 (5), p.722-726
Main Authors: ENRIQUEZ, Miriam L, BALOCH, Zubair W, MONTONE, Kathleen T, ZHANG, Paul J, LIVOLSI, Virginia A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Papillary - metabolism
Carcinoma, Papillary - pathology
CDX2 Transcription Factor
Endocrinopathies
Epithelial Cells - metabolism
Epithelial Cells - pathology
Female
Homeodomain Proteins - metabolism
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Malignant tumors
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyroid. Thyroid axis (diseases)
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Summary:The columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is a rare subtype of PTC that exhibits morphologic features often described as reminiscent of secretory endometrium or colonic adenomas/adenocarcinomas. CDX2, a nuclear transcription factor, is important for intestinal development. It is normally expressed in intestinal epithelium and is also detected in adenoma and adenocarcinomas of the gastrointestinal tract; however, it has also been reported in tumors of other sites with intestinal-type morphologic features. We evaluated CDX2 expression in CCV-PTC and in a thyroid tissue microarray composed of various benign and malignant thyroid lesions. CDX2 expression was identified in 6 (55%) of 11 cases of CCV-PTC, but not in any other benign and malignant thyroid lesions. We conclude that CDX2 is selectively expressed in CCV-PTC and can be used in distinguishing it from other variants of PTC with overlapping morphologic features.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPXE3PUBWVZCGZ